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Inflammation is common to chronic diseases including chronic pain. Diet plays a large role in modulating our immune systems.Dietary modification has the potential to alleviate chronic pain by reducing intake of pro-inflammatory foodstuffs and increasing intake of fruits, vegetables and unsaturated fats, particularly omega-3 fatty acids. Diet and nutritional supplements are important factors in inflammation and pain, and modification of diet in patients with chronic pain should be a part of a comprehensive treatment plan.